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(S)-Coriolic acid
CAS No. 29623-28-7
(S)-Coriolic acid( —— )
Catalog No. M34990 CAS No. 29623-28-7
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name(S)-Coriolic acid
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NoteResearch use only, not for human use.
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Brief Description(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent generated by the reaction of linoleic acid with plant and mammalian lipoxygenases.
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Description(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury.
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In Vitro(S)-Coriolic acid (25μM) causes mitochondrial structural alterations and injury in bronchial epithelium.(S)-Coriolic acid (30 nM; 6 hours; E-FABP-/- keratinocytes) induces K1 expression through NF-κB activation. (S)-Coriolic acid increases the phosphorylation of IκBαat serine 32, which induces IκB degradation and thereby activates NF-κB. (S)-Coriolic acid also increases the phosphorylation of Ikkinase-bat tyrosine 199, which promotes IκBα phosphorylation and subsequent NF-kB activation.
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In Vivo(S)-Coriolic acid (0-0.6 mg per mouse; Intranasally once a day for 3 consecutive days) causes severe airway dysfunction, airway neutrophilia, mitochondrial dysfunction and epithelial injury.Animal Model:BALB/c mice (6-8 weeks)Dosage:0-0.6 mg per mouse Administration:Intranasally once a day for 3 consecutive days Result:BALB/c mice developed features of mitochondrial dysfunction such as reduction in mitochondrial membrane potential, reduction in complex IV activity in lung mitochondria, and increase in the levels of cytochrome c in lung cytosol.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetLipoxygenase
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RecptorLipoxygenase | Mitochondrial Metabolism | PPAR
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Research Area——
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Indication——
Chemical Information
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CAS Number29623-28-7
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Formula Weight296.44
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Molecular FormulaC18H32O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=C/C=C\CCCCCCCC(O)=O)\[C@H](CCCCC)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349.?
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